We guide clinical trial design and estimate budget impact.
To guide clinical trial design, we used real-world data to guide future drug development and treatment strategies including sample size calculations and feasibility assessment. We determine optimal sites for patient recruitment to inform trial implementation. Furthermore, by using the real-world population as a historical control group for comparison, we enhance trial efficiency and cost-effectiveness.
To estimate the budget impact, we quantify disease burden by triangulating multiple data sources, including national claims databases, multi-institutional electronic health records, and disease registries. We visualize these burdens to provide a foundation for future health technology assessments and evaluations of the financial impact of incorporating new medications into health insurance.
