Chang Gung Research Database (CGRD)
Overview
The Chang Gung Research Database (CGRD), the largest multi‐institutional electronic medical records (EMR) collection in Taiwan, provides access to researchers with standardized patient‐level data. It is the first and largest EMR database encompassing multiple medical institutions, covering 6.1% of outpatients and 10.2% of hospitalized patients in Taiwan. The CGRD contains more detailed clinical information that is not available from claims databases, such as Taiwan's National Health Insurance Research Database (NHIRD). In addition to prescriptions, diagnoses, and procedure records, the CGRD includes information from pathological reports and laboratory results such as HbA1c, eGFR. The CGRD can be linked with the Death Registry, enabling comprehensive analyses disease outcomes, and long-term survival.
Shao SC, Chan YY, Kao Yang YH, et al. The Chang Gung Research Database-A multi-institutional electronic medical records database for real-world epidemiological studies in Taiwan. Pharmacoepidemiol Drug Saf. 2019;28(5):593-600. doi:10.1002/pds.4713
Shao SC, Lai EC, Huang TH, et al. The Chang Gung Research Database: Multi-institutional real-world data source for traditional Chinese medicine in Taiwan. Pharmacoepidemiol Drug Saf. 2021;30(5):652-660. doi:10.1002/pds.5208
Selected publications:
Tsai DH, Chuang AT, Liu KH, et al. Sodium-glucose cotransporter 2 (SGLT2) inhibitors and risk of chronic kidney disease-mineral and bone disorders in patients with type 2 diabetes mellitus and stage 1-3 chronic kidney disease. CMAJ. 2025;197(7):E178-E189. Published 2025 Feb 23. doi:10.1503/cmaj.240922
Hu JC, Shao SC, Tsai DH, et al. Use of SGLT2 Inhibitors vs GLP-1 RAs and Anemia in Patients With Diabetes and CKD. JAMA Netw Open. 2024;7(3):e240946. Published 2024 Mar 4. doi:10.1001/jamanetworkopen.2024.0946